Endocrine Abstracts

Background: Adrenocortical carcinomas (ACC) are rare malignant tumours with an incidence of 1 to 2 per million per year.Case Report: A 70 year old lady was admitted with a one month history of new onset hypertension, hypergylcaemia, hirsutism and generalised weakness. On examination she was cushingoid with facial plethora, severe hirsutism, central obesity and severe proximal myopathy. A CT trunk showed a large, lobulated, inhomogeneous, solid left adren...

Background: Hyponatremia is a rare complication of pre eclampsia. We present a case of syndrome of inappropriate ADH secretion (SIADH) in the setting of pre eclampsia.Case Report: A 40 year old lady known to have type 1 diabetes on insulin pump therapy presented with hypertension at 33 weeks gestation. Treatment with labetalol 100 mg bd was initiated but she was admitted at 34 weeks due to lack of BP control. Sodium levels were 136 mmol/L (135–145 m...

Background: Gestational diabetes (GDM) can be driven by mutations or rare variants in various genes associated with monogenic or atypical forms of diabetes. The reported frequency of monogenic defects of beta cell function in GDM varies extensively, in part due to differences in ethnicity, patient ascertainment criteria and techniques used for genetic analysis. The objective was to evaluate the frequency and molecular spectrum of mutations in a curated list of genes associated...